LOGISTICAL CHALLENGES AND ASSUMPTIONS FOR MODELING THE FAILURE OF GLOBAL CESSATION OF ORAL POLIOVIRUS VACCINE (OPV)

Logistical challenges and assumptions for modeling the failure of global cessation of oral poliovirus vaccine (OPV)

Introduction: The inability to successfully stop all use of oral poliovirus vaccine (OPV) as part of the polio endgame and/or the possibilities of reintroduction of live polioviruses after successful OPV cessation may imply the need to restart OPV production and use, either temporarily or permanently.Areas covered: Complementing prior work that exp

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Inverse Kinematics Solution of Articulated Robots Using a Heuristic Approach for Optimizing Joint Displacement

In this work, a new constrained numerical optimization Socks approach is proposed for solving offline the Inverse Kinematics Problem (IKP) of articulated robots, which consists on optimizing the joint displacement while the end effector is positioned and oriented in a desired pose.The novelty of this approach is in the formulation of the optimizati

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Determinants of mosaic chromosomal alteration fitness

Abstract Clonal hematopoiesis (CH) is characterized by the acquisition of a somatic mutation in a hematopoietic stem cell that results in a clonal expansion.These driver mutations can be single nucleotide variants in cancer driver genes or larger structural rearrangements HYALURONIC ACID SERUM called mosaic chromosomal alterations (mCAs).The factor

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